Small Bowel Transplantation: Current Clinical Status

Local Immunosuppression in Clinical Small Bowel Transplantation

LOCAL IMMUNOSUPPRESSION (L-IMS) has been used for many years, particularly in animal experimental organ transplantation. It has also been used in human kidney transplantation. The rationale for this practice is that the most important immunologic events leading to rejection occur in the graft. For instance, it has been demonstrated that local expansion of donor-specific T cells may mediate graf...

Recent Advances in Clinical Practice the Current Status of Small Bowel Transplantation in the Uk and Internationally

Correspondence to: Dr S J Middleton, Unit E7, Department of Gastroenterology, Addenbrooke’s Hospital, Hills Rd, Cambridge CB2 2QQ, UK; stephen.middleton@ addenbrookes.nhs.uk _________________________ S mall intestinal transplantation should now be routinely considered for patients with irreversible intestinal failure and complications of parenteral nutrition (PN). Although technically possible ...

The current status of small bowel transplantation in the UK and internationally.

Correspondence to: Dr S J Middleton, Unit E7, Department of Gastroenterology, Addenbrooke’s Hospital, Hills Rd, Cambridge CB2 2QQ, UK; stephen.middleton@ addenbrookes.nhs.uk _________________________ S mall intestinal transplantation should now be routinely considered for patients with irreversible intestinal failure and complications of parenteral nutrition (PN). Although technically possible ...

Current status of clinical islet transplantation

Current status of clinical islet transplantation.

Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repeated infusions of islets obtained from 2 to 4 donors until normoglycemia is ach...